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KMID : 0359320030430030435
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Korean Journal of Veterinary Research
2003 Volume.43 No. 3 p.435 ~ p.438
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Residue Depletion of Cephalexin in the Flounder (Paralichthys olivaceus)
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Lim, Jong-hwan/임종환
Jang, Beom-su/Park, Byung-kwon/Yun, Hyo\-in/장범수/박병권/윤효인
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Abstract
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The objective of this study was to investigate the residue depletion of cephalexin in the flounder (Paralichrhys olivaceus) after multiple oral administrations and to establish the appropriate withdrawal time for edible tissues. A highly sensitive and specific method for the determination of cephalexin in the serum of flounder by LC/MS was developed and validated. Mean recoveries from serum were 87.2％ (ranged from 81.2％ to 94.5％) for cepalexin. Recovery and precision met the criteria for the guideline of residual analysis of veterinary drugs by the National Veterinary Research and Quarantine Service (NVRQS) in Korea. The limit of detection and limit of quantitation of cephalexin were 10 ng/ml and 50 ng/ml, respectively. Residual levels of cephalexin in muscle samples were estimated with 95％ tolerance limit and 95％ confidence to fall below the MRL after a withdrawal time of 4 days and 5 days for the 40 and 160 mg/kg/day, respectively.
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